Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling

被引：38

作者：

Magnani, Luca ^{[1
]}

Lupien, Mathieu ^{[1
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Ontario Canc Inst, Toronto, ON, Canada

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2014年 / 382卷 / 01期

关键词：

Epigenetic; Chromatin; Estrogen receptor; Transcriptional regulation; Pioneer factor; FOXA1; DNASE-I HYPERSENSITIVITY; LONG-RANGE INTERACTION; ER-ALPHA; RESPONSIVE PROMOTERS; REGULATORY ELEMENTS; ANDROGEN RECEPTOR; DISTAL ENHANCER; PIONEER FACTORS; NONCODING RNAS; CHIP-SEQ;

D O I：

10.1016/j.mce.2013.04.026

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The oestrogen receptor alpha (ESR1) is a transcription factor that potentiates the response to diverse stimuli, including oestrogen and growth factors, in various tissue types. Its recruitment to the DNA is directly regulated by the chromatin landscape, inclusive of chromatin compaction and epigenetic modifications. In this review we discuss our current understanding of the interplay between ESR1 signaling and the chromatin landscape. We present how the chromatin landscape primes the lineage-specific response and contributes to stimuli-specific signaling. Finally, we discuss recent efforts to decipher the relationship between genetic and epigenetic as it relates to ESR1 signaling in breast cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：633 / 641

页数：9

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