Configurable 3D-Printed millifluidic and microfluidic 'lab on a chip' reactionware devices

被引：415

作者：

Kitson, Philip J. ^{[1
]}

Rosnes, Mali H. ^{[1
]}

Sans, Victor ^{[1
]}

Dragone, Vincenza ^{[1
]}

Cronin, Leroy ^{[1
]}

机构：

[1] Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

LAB ON A CHIP | 2012年 / 12卷 / 18期

基金：

英国工程与自然科学研究理事会;

关键词：

GOLD NANOPARTICLES; FLOW; EVOLUTION; REACTOR;

D O I：

10.1039/c2lc40761b

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We utilise 3D design and 3D printing techniques to fabricate a number of miniaturised fluidic 'reactionware' devices for chemical syntheses in just a few hours, using inexpensive materials producing reliable and robust reactors. Both two and three inlet reactors could be assembled, as well as one-inlet devices with reactant 'silos' allowing the introduction of reactants during the fabrication process of the device. To demonstrate the utility and versatility of these devices organic (reductive amination and alkylation reactions), inorganic (large polyoxometalate synthesis) and materials (gold nanoparticle synthesis) processes were efficiently carried out in the printed devices.

引用

页码：3267 / 3271

页数：5

共 21 条

[1] Omnidirectional Printing of Flexible, Stretchable, and Spanning Silver Microelectrodes [J].

Ahn, Bok Y. ;

Duoss, Eric B. ;

Motala, Michael J. ;

Guo, Xiaoying ;

Park, Sang-Il ;

Xiong, Yujie ;

Yoon, Jongseung ;

Nuzzo, Ralph G. ;

Rogers, John A. ;

Lewis, Jennifer A. .

SCIENCE, 2009, 323 (5921) :1590-1593

[2] ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing [J].

Carter, Catherine F. ;

Lange, Heiko ;

Ley, Steven V. ;

Baxendale, Ian R. ;

Wittkamp, Brian ;

Goode, Jon G. ;

Gaunt, Nigel L. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2010, 14 (02) :393-404

[3] Modular Redox-Active Inorganic Chemical Cells: iCHELLs [J].

Cooper, Geoffrey J. T. ;

Kitson, Philip J. ;

Winter, Ross ;

Zagnoni, Michele ;

Long, De-Liang ;

Cronin, Leroy .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (44) :10373-10376

[4] Facile Stoichiometric Reductions in Flow: An Example of Artemisinin [J].

Fan, Xiaolei ;

Sans, Victor ;

Yaseneva, Polina ;

Plaza, Dorota D. ;

Williams, Jonathan ;

Lapkin, Alexei .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2012, 16 (05) :1039-1042

[5] Rapid prototyping for injection moulded integrated microfluidic devices and diffractive element arrays [J].

Hulme, JP ;

Mohr, S ;

Goddard, NJ ;

Fielden, PR .

LAB ON A CHIP, 2002, 2 (04) :203-206

[6] Soft Robotics for Chemists [J].

Ilievski, Filip ;

Mazzeo, Aaron D. ;

Shepherd, Robert E. ;

Chen, Xin ;

Whitesides, George M. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (08) :1890-1895

[7] Flow chemistry using milli- and microstructured reactors-From conventional to novel process windows [J].

Illg, Tobias ;

Loeb, Patrick ;

Hessel, Volker .

BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (11) :3707-3719

[8] Size Evolution of Gold Nanoparticles in a Millifluidic Reactor [J].

Li, Yuehao ;

Sanampudi, Ashwin ;

Reddy, Vanga Raji ;

Biswas, Sanchita ;

Nandakumar, Krishnaswamy ;

Yemane, Dawit ;

Goettert, Jost ;

Kumar, Challa S. S. R. .

CHEMPHYSCHEM, 2012, 13 (01) :177-182

[9]

Marks P, 2011, NEW SCI, V2823, P17, DOI DOI 10.1016/S0262-4079(11)61817-4

[10] Solution-Phase Monitoring of the Structural Evolution of a Molybdenum Blue Nanoring [J].

Miras, Haralampos N. ;

Richmond, Craig J. ;

Long, De-Liang ;

Cronin, Leroy .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (08) :3816-3824

← 1 2 3 →