Systems biology is the comprehensive and quantitative analysis of the interactions between all of the components of biological systems over time. Systems biology involves an iterative cycle, in which emerging biological problems drive the development of new technologies and computational tools. These technologies and tools then open new frontiers that revolutionize biology. Innate immunity is well suited for systems analysis, because the relevant cells can be isolated in various functional states and their interactions can be reconstituted in a biologically meaningful manner. Application of the tools of systems biology to the innate immune system will enable comprehensive analysis of the complex interactions that maintain the difficult balance between host defense and inflammatory disease. In this review, we discuss innate immunity in the context of the systems biology concepts, emergence, robustness, and modularity, and we describe emerging technologies we are applying in our systems-level analyses. These technologies include genomics, proteomics, computational analysis, forward genetics screens, and analyses that link human genetic polymorphisms to disease resistance.
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Hitotsumatsu, Osamu
Ahmad, Regina-Celeste
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Ahmad, Regina-Celeste
Tavares, Rita
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Tavares, Rita
Wang, Min
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Wang, Min
Philpott, Dana
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Inst Pasteur, Grp Immunite Innee Signalisat, Paris, FranceUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Philpott, Dana
Turer, Emre E.
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Turer, Emre E.
Lee, Bettina L.
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Lee, Bettina L.
Shiffin, Nataliya
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Shiffin, Nataliya
Advincula, Rommel
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Advincula, Rommel
Malynn, Barbara A.
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Malynn, Barbara A.
Werts, Catherine
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Inst Pasteur, Grp Immunite Innee Signalisat, Paris, FranceUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Werts, Catherine
Ma, Averil
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
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Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Hitotsumatsu, Osamu
Ahmad, Regina-Celeste
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Ahmad, Regina-Celeste
Tavares, Rita
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机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Tavares, Rita
Wang, Min
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Wang, Min
Philpott, Dana
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h-index: 0
机构:
Inst Pasteur, Grp Immunite Innee Signalisat, Paris, FranceUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Philpott, Dana
Turer, Emre E.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Turer, Emre E.
Lee, Bettina L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Lee, Bettina L.
Shiffin, Nataliya
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Shiffin, Nataliya
Advincula, Rommel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Advincula, Rommel
Malynn, Barbara A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Malynn, Barbara A.
Werts, Catherine
论文数: 0引用数: 0
h-index: 0
机构:
Inst Pasteur, Grp Immunite Innee Signalisat, Paris, FranceUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA
Werts, Catherine
Ma, Averil
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Gastroenterol, Program Biomed Sci,UCSF Colitis Ctr, San Francisco, CA 94143 USA