Beyond PPARs and Metformin: New Insulin Sensitizers for the Treatment of Type 2 Diabetes

被引：11

作者：

Carpino, Philip A. ^{[1
]}

Hepworth, David ^{[1
]}

机构：

[1] Pfizer Pharma Therapeut, Dept Worldwide Med Chem, Cambridge, MA USA

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 47 | 2012年 / 47卷

关键词：

TYROSINE-PHOSPHATASE; 1B; MICE LACKING; PTP1B INHIBITORS; ADIPOSE-TISSUE; RESISTANCE; SENSITIVITY; DISCOVERY; GHRELIN; POTENT; GAMMA;

D O I：

10.1016/B978-0-12-396492-2.00012-6

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

引用

页码：177 / 192

页数：16

共 66 条

[1]

Ackermann J., 2010, International Patent, Patent No. [2010/130665, 2010130665, WO 2010130665 Al]

[2]

[Anonymous], DIABETES CARE

[3]

Arakawa K.N., 2010, Patent No. [WO2010104195A1, 2010104195]

[4]

Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes [J].

Bento, JL ;

Palmer, ND ;

Mychaleckyj, JC ;

Lange, LA ;

Langefeld, CD ;

Rich, SS ;

Freedman, BI ;

Bowden, DW .

DIABETES, 2004, 53 (11) :3007-3012

[5]

Birch AM, 2010, CURR OPIN DRUG DISC, V13, P489

[6]

The isoform-specific functions of the c-Jun N-terminal kinases (JNKs): differences revealed by gene targeting [J].

Bogoyevitch, Marie A. .

BIOESSAYS, 2006, 28 (09) :923-934

[7]

Recent Advances in Acetyl-CoA Carboxylase Inhibitors [J].

Bourbeau, Matthew P. ;

Allen, John G. ;

Gu, Wei .

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45, 2010, 45 :95-108

[8]

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism [J].

Cao, Haiming ;

Gerhold, Kristin ;

Mayers, Jared R. ;

Wiest, Michelle M. ;

Watkins, Steven M. ;

Hotamisligil, Goekhan S. .

CELL, 2008, 134 (06) :933-944

[9]

Insulin resistance: Cellular and clinical concepts [J].

Cefalu, WT .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2001, 226 (01) :13-26

[10]

Centers for Disease Control Statistics, 2011, CTR DIS CONTR STAT 2

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