Ulysses - an application for the projection of molecular interactions across species

被引：17

作者：

Kemmer, D

Huang, Y

Shah, SP

Lim, J

Brumm, J

Yuen, MMS

Ling, J

Xu, T

Wasserman, WW ^{[1
]}

Ouellette, BFF

机构：

[1] Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada

[2] Karolinska Inst, Ctr Genom & Bioinformat, S-17177 Stockholm, Sweden

[3] Univ British Columbia, UBC Bioinformat Ctr, Vancouver, BC V6T 1Z4, Canada

[4] Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada

[5] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

[6] Univ British Columbia, Dept Comp Sci, Vancouver, BC V6T 1Z4, Canada

来源：

GENOME BIOLOGY | 2005年 / 6卷 / 12期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1186/gb-2005-6-12-r106

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interactions detected in various species. Ulysses was designed to perform such Interolog Analysis by the projection of model organism interaction data onto homologous human proteins, and thus serves as an accelerator for the analysis of uncharacterized human proteins. The relevance of projections was assessed and validated against published reference collections. All source code is freely available, and the Ulysses system can be accessed via a web interface http://www.cisreg.ca/ulysses.

引用

页数：11

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