Iron-Catalyzed Cross-Coupling of N-Heterocyclic Chlorides and Bromides with Arylmagnesium Reagents

被引：79

作者：

Kuzmina, Olesya M. ^{[1
]}

Steib, Andreas K. ^{[1
]}

Flubacher, Dietmar ^{[2
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

[2] Novartis Pharma AG, CH-4056 Basel, Switzerland

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 18期

基金：

欧洲研究理事会;

关键词：

ARYL GRIGNARD-REAGENTS; SECONDARY ALKYL-HALIDES; BETA-HYDROGENS; BOND FORMATION; COMPLEX; TOSYLATES; EFFICIENT; OXIDANT; LIGAND; SALTS;

D O I：

10.1021/ol302136c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.

引用

页码：4818 / 4821

页数：4

共 77 条

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