Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells

被引：585

作者：

Merad, Miriam ^{[1
,2
]}

Ginhoux, Florent ^{[1
,2
]}

Collin, Matthew ^{[1
,2
,3
]}

机构：

[1] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

[3] Newcastle Univ, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2455

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin(+) DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin+ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.

引用

页码：935 / 947

页数：13

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