A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

被引：62

作者：

Akdemir, Fazile Nur Ekinci ^{[1
]}

Gulcin, Ilhami ^{[2
,3
]}

Karagoz, Berna ^{[4
]}

Soslu, Recep ^{[5
]}

Alwasel, Saleh H. ^{[3
]}

机构：

[1] Ibrahim Cecen Univ Agri, Dept Nutr & Dietet, Hlth Sch, Agri, Turkey

[2] Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey

[3] King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia

[4] Ibrahim Cecen Univ Agri, Fac Pharm, Dept Pharmacol, Agri, Turkey

[5] Bartin Univ, Phys Educ & Sports, Bartin, Turkey

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2016年 / 31卷

关键词：

Antioxidant activity; ellagic acid; hesperidin; ischemia/reperfusion injury; skeletal muscle; ISCHEMIA-REPERFUSION INJURY; INDUCED OXIDATIVE STRESS; IN-VITRO ANTIOXIDANT; RADICAL SCAVENGING ACTIVITIES; LYOPHILIZED AQUEOUS EXTRACT; POLYPHENOL CONTENTS; PHENOLIC-COMPOUNDS; CAFFEIC ACID; ANTIRADICAL ACTIVITIES; LUNG CARCINOGENESIS;

D O I：

10.1080/14756366.2016.1220378

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2 h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2 h. EA (100 mg/kg) has been applied orally before ischemia/reperfusion in the EA+I/R group. HES (100 mg/kg) has been given orally in the HES+1/R group. The left gastrocnemius muscle has been harvested and stored immediately at -80 degrees C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p<0.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p<0.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA+I/R and HES+I/R groups.

引用

页码：114 / 118

页数：5

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