Valve-based flow focusing for drop formation

被引：85

作者：

Abate, Adam R.

Romanowsky, Mark B.

Agresti, Jeremy J.

Weitz, David A. ^{[1
]}

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02139 USA

来源：

APPLIED PHYSICS LETTERS | 2009年 / 94卷 / 02期

基金：

美国国家科学基金会;

关键词：

drops; microfluidics; CHIP;

D O I：

10.1063/1.3067862

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Microfluidic devices can produce highly monodisperse drops at kilohertz rates using flow-focus drop formation. We use single-layer membrane valves to control, in real time, the dimensions of the flow-focus drop makers. This allows drop size and frequency to be controlled in real time and without adjusting flow rates.

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页数：3

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共 20 条

[1] Single-layer membrane valves for elastomeric microfluidic devices [J].

Abate, A. R. ;

Weitz, D. A. .

APPLIED PHYSICS LETTERS, 2008, 92 (24)

[2] Dielectrophoretic manipulation of drops for high-speed microfluidic sorting devices [J].

Ahn, K ;

Kerbage, C ;

Hunt, TP ;

Westervelt, RM ;

Link, DR ;

Weitz, DA .

APPLIED PHYSICS LETTERS, 2006, 88 (02) :1-3

[3] Controlled microfluidic interfaces [J].

Atencia, J ;

Beebe, DJ .

NATURE, 2005, 437 (7059) :648-655

[4] Producing droplets in parallel microfluidic systems [J].

Barbier, V. ;

Willaime, H. ;

Tabeling, P. ;

Jousse, F. .

PHYSICAL REVIEW E, 2006, 74 (04)

[5] Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans [J].

Chung, Kwanghun ;

Crane, Matthew M. ;

Lu, Hang .

NATURE METHODS, 2008, 5 (07) :637-643

[6] Control of serial microfluidic droplet size gradient by step-wise ramping of flow rates [J].

Collins, John ;

Lee, Abraham Phillip .

MICROFLUIDICS AND NANOFLUIDICS, 2007, 3 (01) :19-25

[7]

*EPAPS, EAPPLAB94020902

[8] Water in carbon dioxide microemulsions: An environment for hydrophiles including proteins [J].

Johnston, KP ;

Harrison, KL ;

Clarke, MJ ;

Howdle, SM ;

Heitz, MP ;

Bright, FV ;

Carlier, C ;

Randolph, TW .

SCIENCE, 1996, 271 (5249) :624-626

[9] Drop-based microfluidic devices for encapsulation of single cells [J].

Koester, Sarah ;

Angile, Francesco E. ;

Duan, Honey ;

Agresti, Jeremy J. ;

Wintner, Anton ;

Schmitz, Christian ;

Rowat, Amy C. ;

Merten, Christoph A. ;

Pisignano, Dario ;

Griffiths, Andrew D. ;

Weitz, David A. .

LAB ON A CHIP, 2008, 8 (07) :1110-1115

[10] Electric control of droplets in microfluidic devices [J].

Link, DR ;

Grasland-Mongrain, E ;

Duri, A ;

Sarrazin, F ;

Cheng, ZD ;

Cristobal, G ;

Marquez, M ;

Weitz, DA .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (16) :2556-2560