A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs

被引：44

作者：

Cai, Y ^{[1
]}

Ling, CC ^{[1
]}

Bundle, DR ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Alberta Ingenu Ctr Carbohydrate Sci, Edmonton, AB T6G 2G2, Canada

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 06期

关键词：

D O I：

10.1039/b516333a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sphingosine, sphinganines and phytosphingosines and their analogs were synthesized by an aldol condensation between an iminoglycinate bearing a (+)-(1R,2R,5R)-2-hydroxy-3-pinanone group as chiral auxiliary and an appropriate aldehyde. All condensations proceeded with excellent enantioselectivity to generate the (2S,3R)-D-erythro structures in good yields.

引用

页码：1140 / 1146

页数：7

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