Rapid reaction scanning of solid phase chemistry using resins incorporating analytical constructs

被引：27

作者：

Murray, PJ

Kay, C

Scicinski, JJ

McKeown, SC

Watson, SP

Carr, RAE

机构：

[1] Univ Cambridge, Chem Lab, Glaxo Wellcome Cambridge Chem Lab, Cambridge CB2 1EW, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 30期

关键词：

ionisation; labelling; mass spectrometry; solid-phase synthesis;

D O I：

10.1016/S0040-4039(99)01042-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two analytical constructs, based on orthogonally cleavable linkers, are reported which facilitate the mass spectral analysis of solid phase chemistry. The chemical compatibility and orthogonality of the linkers were established in a parallel reaction study using constructs prepared specifically for the purpose. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5609 / 5612

页数：4

共 13 条

[1] Solid-phase organic reactions III: A review of the literature Nov 96 Dec 97
Booth, S
Hermkens, PHH
Ottenheijm, HCJ
Rees, DC
[J]. TETRAHEDRON, 1998, 54 (51) : 15385 - 15443
[2] Brown AR, 1998, SYNLETT, P817
[3] Brown RCD, 1998, J CHEM SOC PERK T 1, P3293
[4] BUNIN BA, 1998, COMBINATORIAL INDEX, P213
[5] Direct monitoring of organic reactions on polymeric supports
Carrasco, MR
Fitzgerald, MC
Oda, Y
Kent, SBH
[J]. TETRAHEDRON LETTERS, 1997, 38 (36) : 6331 - 6334
[6] Versatile Dde-based primary amine linkers for solid phase synthesis
Chhabra, SR
Khan, AN
Bycroft, BW
[J]. TETRAHEDRON LETTERS, 1998, 39 (21) : 3585 - 3588
[7] FITCH WL, 1997, ANN REPORTS COMBINAT, V1, P59
[8] 2-NITROBENZENESULFONAMIDES AND 4-NITROBENZENESULFONAMIDES - EXCEPTIONALLY VERSATILE MEANS FOR PREPARATION OF SECONDARY-AMINES AND PROTECTION OF AMINES
FUKUYAMA, T
JOW, CK
CHEUNG, M
[J]. TETRAHEDRON LETTERS, 1995, 36 (36) : 6373 - 6374
[9] Isotope or mass encoding of combinatorial libraries
Geysen, HM
Wagner, CD
Bodnar, WM
Markworth, CJ
Parke, GJ
Schoenen, FJ
Wagner, DS
Kinder, DS
[J]. CHEMISTRY & BIOLOGY, 1996, 3 (08): : 679 - 688
[10] A novel, chemically robust, amine releasing linker
Kay, C
Murray, PJ
Sandow, L
Holmes, AB
[J]. TETRAHEDRON LETTERS, 1997, 38 (39) : 6941 - 6944

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