Inhibitory effects of monoacylated 2-O-β-galactosylglycerols on Epstein-Barr virus activation:: the significant role of the hexanoyl chain

被引：22

作者：

Colombo, D

Compostella, F

Ronchettia, F

Scala, A

Toma, L

Mukainaka, T

Nagatsu, A

Konoshima, T

Tokuda, H

Nishino, H

机构：

[1] Univ Milan, Dipartimento Chim & Biochim Med, I-20133 Milan, Italy

[2] Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

[4] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan

[5] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

CANCER LETTERS | 1999年 / 143卷 / 01期

关键词：

glycosylglycerols; glycoglycerolipids; cancer chemoprevention; Epstein-Barr virus early antigen;

D O I：

10.1016/S0304-3835(99)00175-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three series of mononcyl-2-O-beta-D-galactosylglycerols bearing an acyl chain of varying length, from C-4 to C-10 were studied due to their antitumor promoting effects on the activation of the Epstein-Barr virus early antigen (EBV-EA), such activation being induced by the tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA). This study indicates that it is more the length of the acyl chain that is important for the activity, six carbon atoms resulting in maximum effect, rather than the position of the eater function and the nature of the sugar (galactose or glucose). (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

共 8 条

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