Bioctive glycoglycerolipid analogues:: an expeditious enzymatic approach to mono- and diesters of 2-O-β-D-galactoglycerol

被引：16

作者：

Colombo, D

Ronchetti, F

Scala, A

Toma, L

机构：

[1] Univ Milan, Dipartimento Chim & Biochim Med, I-20133 Milan, Italy

[2] Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(98)00207-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-O-beta-D-Galactosylglycerol 1 was submitted to acylation using Pseudomonas cepacia or Candida antarctica lipases as catalysts and 2,2,2-trifluoroethyl esters of butanoic, hexanoic, octanoic or decanoic acid as acyl carriers. Taking advantage of the high diastereoselectivity and regioselectivity of the two enzymes, the 1-O-, 3-O-, 6'-O-acyl and the 1,6'-di-O-acylderivatives of 1 were obtained pure or in an appreciably enriched form. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2113 / 2119

页数：7

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