Sandmeyer Trifluoromethylation of Arenediazonium Tetrafluoroborates

被引：179

作者：

Danoun, Gregory ^{[1
]}

Bayarmagnai, Bilguun ^{[1
]}

Gruenberg, Matthias F. ^{[1
]}

Goossen, Lukas J. ^{[1
]}

机构：

[1] Tech Univ Kaiserslautern, FB Chem Organ Chem, D-67663 Kaiserslautern, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 31期

关键词：

copper; diazonium salts; Sandmeyer reaction; trifluoromethylation; COPPER-CATALYZED TRIFLUOROMETHYLATION; NUCLEOPHILIC TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; MEDIATED TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; AROMATIC-COMPOUNDS; CONVENIENT METHOD; BORONIC ACIDS; ARYL HALIDES; ARENES;

D O I：

10.1002/anie.201304276

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl-copper complex generated in situ from CuSCN and the inexpensive, easy-to-use trifluoromethylating reagent Me3Si-CF3 (see scheme). This Sandmeyer-type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7972 / 7975

页数：4

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