Antiproliferative activity and synthesis of 8-prenylnaringenin derivatives by demethylation of 7-O- and 4'-O-substituted isoxanthohumols

被引：18

作者：

Aniol, Miroslaw ^{[1
]}

Swiderska, Anna ^{[1
]}

Stompor, Monika ^{[1
]}

Zolnierczyk, Anna Katarzyna ^{[1
]}

机构：

[1] Wroclaw Univ Environm & Life Sci, Dept Chem, PL-50375 Wroclaw, Poland

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 12期

关键词：

Hop flavonoids; Phytoestrogens; Antitumor agents; Antiproliferative activity; MCF-7; HT-29; CCRF/CEM; HUMULUS-LUPULUS L; MAGNESIUM IODIDE ETHERATE; CANCER CELL-LINES; EFFICIENT SYNTHESIS; PHYTOESTROGEN; 8-PRENYLNARINGENIN; ALLYL ETHERS; XANTHOHUMOL; HOPS; APOPTOSIS; GROWTH;

D O I：

10.1007/s00044-011-9967-8

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Several analogues of 7-O- and 4'-O-substituted isoxanthohumol and 8-prenylnaringenin, the strongest known phytoestrogen and potential anticancerogenic agent, were synthesized. Acyl, alkyl, and allyl derivatives of isoxanthohumol underwent the demethylation process using MgI2 x 2Et(2)O in anhydrous THF with the yields of 61-89%. Some of the compounds approached the international criteria of antiproliferative activity (4 mu g/ml) for synthetic agents against the human cancer cell lines.

引用

页码：4230 / 4238

页数：9

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