Acidocalcisome:: A novel Ca2+ storage compartment in trypanosomatids and apicomplexan parasites

被引：103

作者：

Docampo, R ^{[1
]}

Moreno, SNJ ^{[1
]}

机构：

[1] Univ Illinois, Coll Vet Med, Dept Pathobiol, Mol Parasitol Lab, Urbana, IL 61802 USA

来源：

PARASITOLOGY TODAY | 1999年 / 15卷 / 11期

关键词：

D O I：

10.1016/S0169-4758(99)01531-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Acidocalcisomes are novel acidic Ca2+ storage organelles found in trypanosomatids and apicomplexan parasites, abundant in the intracellular stages of these parasites, and characterized by their high electron density, and high content of phosphorus, Ca2+, Mg2+, Na+ and Zn2+. A number of energy-utilizing pumps and exchangers have been found in these organelles, which underlines their importance in the homeostasis of different elements, as discussed here by Roberto Docampo and Silvia Moreno.

引用

页码：443 / 448

页数：6

共 54 条

[1] Functional expression of a vacuolar-type H+-ATPase in the plasma membrane and intracellular vacuoles of Trypanosoma cruzi [J].

Benchimol, M ;

de Souza, W ;

Vanderheyden, N ;

Zhong, L ;

Lu, HG ;

Moreno, SNJ ;

Docampo, R .

BIOCHEMICAL JOURNAL, 1998, 332 :695-702

[2] CHANGES IN ORTHO-PHOSPHATE, PYROPHOSPHATE AND LONG-CHAIN POLYPHOSPHATE LEVELS IN LEISHMANIA-MAJOR PROMASTIGOTES INCUBATED WITH AND WITHOUT GLUCOSE [J].

BLUM, JJ .

JOURNAL OF PROTOZOOLOGY, 1989, 36 (03) :254-257

[3] Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids:: Pyruvate, phosphate dikinase [J].

Bringaud, F ;

Baltz, D ;

Baltz, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :7963-7968

[4] G-PROTEIN REGULATION OF THE NA+/H+ ANTIPORTER IN XENOPUS-LAEVIS OOCYTES - INVOLVEMENT OF PROTEIN-KINASE-A AND PROTEIN-KINASE-C [J].

BUSCH, S ;

WIELAND, T ;

ESCHE, H ;

JAKOBS, KH ;

SIFFERT, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (30) :17898-17901

[5]

BUSH J, 1994, J CELL SCI, V107, P2801

[6] ROLE OF ACIDIC COMPARTMENTS IN TRYPANOSOMA-BRUCEI, WITH SPECIAL REFERENCE TO LOW-DENSITY-LIPOPROTEIN PROCESSING [J].

COPPENS, I ;

BAUDHUIN, P ;

OPPERDOES, FR ;

COURTOY, PJ .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1993, 58 (02) :223-232

[7] CALCINEURIN-DEPENDENT GROWTH-CONTROL IN SACCHAROMYCES-CEREVISIAE MUTANTS LACKING PMC1, A HOMOLOG OF PLASMA-MEMBRANE CA2+ ATPASES [J].

CUNNINGHAM, KW ;

FINK, GR .

JOURNAL OF CELL BIOLOGY, 1994, 124 (03) :351-363

[8] INTRACELLULAR CA2(+) STORAGE IN ACIDOCALCISOMES OF TRYPANOSOMA-CRUZI [J].

DOCAMPO, R ;

SCOTT, DA ;

VERCESI, AE ;

MORENO, SNJ .

BIOCHEMICAL JOURNAL, 1995, 310 :1005-1012

[9] The role of Ca2+ in the process of cell invasion by intracellular parasites [J].

Docampo, R ;

Moreno, SNJ .

PARASITOLOGY TODAY, 1996, 12 (02) :61-65

[10] TRYPANOSOMA-CRUZI - ELEMENTAL COMPOSITION HETEROGENEITY OF CLONED STOCKS [J].

DVORAK, JA ;

ENGEL, JC ;

LEAPMAN, RD ;

SWYT, CR ;

PELLA, PA .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1988, 31 (01) :19-26

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