Transcription factors drive B cell development

被引：67

作者：

Hagman, J ^{[1
]}

Lukin, K ^{[1
]}

机构：

[1] Natl Jewish Med & Res Ctr, Integrated Dept Immunol, Denver, CO 80206 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2006年 / 18卷 / 02期

关键词：

D O I：

10.1016/j.coi.2006.01.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transcription factors including PU.1, EM and early B cell factor (EBF) are essential for the earliest stages of B lymphocyte development. Recent advances suggest that, although PU.1 initiates events leading to B lymphopoiesis, it might be dispensable at later stages of development. E2A proteins are also crucial for B cell lineage determination, as shown by the pluripotency of E2A-deficient progenitors. Both PUA and E2A are required for expression of EBF. EBF activates the early program of genes unique to 13 cells, including the lineage commitment factor Pax5. EBF also facilitates the function of Pax5 by mediating epigenetic changes necessary for the function of Pax5 at gene targets. Together, these proteins function in a hierarchy of factors that orchestrates B cell development.

引用

页码：127 / 134

页数：8

共 67 条

[41]

Nutt SL, 1999, NATURE, V401, P556, DOI 10.1038/44076

[42] Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A [J].

O'Riordan, M ;

Grosschedl, R .

IMMUNITY, 1999, 11 (01) :21-31

[43] The development of functional B lymphocytes in conditional PU.1 knock-out mice [J].

Polli, M ;

Dakic, A ;

Light, A ;

Wu, L ;

Tarlinton, DM ;

Nutt, SL .

BLOOD, 2005, 106 (06) :2083-2090

[44] Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors [J].

Rolink, AG ;

Nutt, SL ;

Melchers, F ;

Busslinger, M .

NATURE, 1999, 401 (6753) :603-606

[45] E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells [J].

Romanow, WJ ;

Langerak, AW ;

Goebel, P ;

Wolvers-Tettero, ILM ;

van Dongen, JJM ;

Feeney, AJ ;

Murre, C .

MOLECULAR CELL, 2000, 5 (02) :343-353

[46] Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1 [J].

Rosenbauer, F ;

Owens, BM ;

Yu, L ;

Tumang, JR ;

Steidl, U ;

Kutok, JL ;

Clayton, LK ;

Wagner, K ;

Scheller, M ;

Iwasaki, H ;

Liu, CH ;

Hackanson, B ;

Akashi, K ;

Leutz, A ;

Rothstein, TL ;

Plass, C ;

Tenen, DG .

NATURE GENETICS, 2006, 38 (01) :27-37

[47] E-proteins directly regulate expression of activation-induced deaminase in mature B cells [J].

Sayegh, CE ;

Quong, MW ;

Agata, Y ;

Murre, C .

NATURE IMMUNOLOGY, 2003, 4 (06) :586-593

[48] PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors [J].

Scott, EW ;

Fisher, RC ;

Olson, MC ;

Kehrli, EW ;

Simon, MC ;

Singh, H .

IMMUNITY, 1997, 6 (04) :437-447

[49] REQUIREMENT OF TRANSCRIPTION FACTOR PU.1 IN THE DEVELOPMENT OF MULTIPLE HEMATOPOIETIC LINEAGES [J].

SCOTT, EW ;

SIMON, MC ;

ANASTASI, J ;

SINGH, H .

SCIENCE, 1994, 265 (5178) :1573-1577

[50] Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A [J].

Seet, CS ;

Brumbaugh, RL ;

Kee, BL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (12) :1689-1700

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