Transcription factors drive B cell development

被引：67

作者：

Hagman, J ^{[1
]}

Lukin, K ^{[1
]}

机构：

[1] Natl Jewish Med & Res Ctr, Integrated Dept Immunol, Denver, CO 80206 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2006年 / 18卷 / 02期

关键词：

D O I：

10.1016/j.coi.2006.01.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transcription factors including PU.1, EM and early B cell factor (EBF) are essential for the earliest stages of B lymphocyte development. Recent advances suggest that, although PU.1 initiates events leading to B lymphopoiesis, it might be dispensable at later stages of development. E2A proteins are also crucial for B cell lineage determination, as shown by the pluripotency of E2A-deficient progenitors. Both PUA and E2A are required for expression of EBF. EBF activates the early program of genes unique to 13 cells, including the lineage commitment factor Pax5. EBF also facilitates the function of Pax5 by mediating epigenetic changes necessary for the function of Pax5 at gene targets. Together, these proteins function in a hierarchy of factors that orchestrates B cell development.

引用

页码：127 / 134

页数：8

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