MaGe:: a microbial genome annotation system supported by synteny results

被引：302

作者：

Vallenet, D

Labarre, L

Rouy, Z

Barbe, V

Bocs, S

Cruveiller, S

Lajus, A

Pascal, G

Scarpelli, C

Médigue, C

机构：

[1] CNRS, UMR 8030, F-91057 Evry, France

[2] Genoscope, F-91057 Evry, France

来源：

NUCLEIC ACIDS RESEARCH | 2006年 / 34卷 / 01期

关键词：

D O I：

10.1093/nar/gkj406

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnifying Genomes (MaGe) is a microbial genome annotation system based on a relational database containing information on bacterial genomes, as well as a web interface to achieve genome annotation projects. Our system allows one to initiate the annotation of a genome at the early stage of the finishing phase. MaGe's main features are (i) integration of annotation data from bacterial genomes enhanced by a gene coding re-annotation process using accurate gene models, (ii) integration of results obtained with a wide range of bioinformatics methods, among which exploration of gene context by searching for conserved synteny and reconstruction of metabolic pathways, (iii) an advanced web interface allowing multiple users to refine the automatic assignment of gene product functions. MaGe is also linked to numerous well-known biological databases and systems. Our system has been thoroughly tested during the annotation of complete bacterial genomes (Acinetobacter baylyi ADP1, Pseudoalteromonas haloplanktis, Frankia alni) and is currently used in the context of several new microbial genome annotation projects. In addition, MaGe allows for annotation curation and exploration of already published genomes from various genera (e.g. Yersinia, Bacillus and Neisseria). MaGe can be accessed at http://www.genoscope.cns.fr/agc/mage.

引用

页码：53 / 65

页数：13

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