Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa

被引：26

作者：

Wiegand, Irith ^{[1
]}

Marr, Alexandra K. ^{[1
]}

Breidenstein, Elena B. M. ^{[1
]}

Schurek, Kristen N. ^{[1
]}

Taylor, Patrick ^{[1
]}

Hancock, Robert E. W. ^{[1
]}

机构：

[1] Univ British Columbia, Ctr Microbiol Dis & Immun Res, Vancouver, BC V6T 1Z4, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 10期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

D O I：

10.1128/AAC.00233-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958 and RadA (PA4609).

引用

页码：3810 / 3813

页数：4

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