Emerging array-based technologies in proteomics

被引：32

作者：

Mirzabekov, A

Kolchinsky, A

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

[2] Hlth Front Line Ltd, Champaign, IL 61821 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 01期

关键词：

D O I：

10.1016/S1367-5931(01)00286-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microarray format is the method of choice for high-throughput hybridization of nucleic acids. Lately, microarray strategy has been applied to broad studies of interactions of proteins with other molecules. The diversity of these interactions and variations of the properties of proteins present new challenges to microchip technology. Significant achievements have been reported. In particular, three-dimensional (gel-based) chips can be manufactured with limited resources and offer flexibility, capacity, homogeneous solvent environment and the ability to record processes in real time and in variable conditions.

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页码：70 / 75

页数：6

相关论文

共 31 条

[1] Protein microchips: Use for immunoassay and enzymatic reactions [J].

Arenkov, P ;

Kukhtin, A ;

Gemmell, A ;

Voloshchuk, S ;

Chupeeva, V ;

Mirzabekov, A .

ANALYTICAL BIOCHEMISTRY, 2000, 278 (02) :123-131

[2] Protein patterning [J].

Blawas, AS ;

Reichert, WM .

BIOMATERIALS, 1998, 19 (7-9) :595-609

[3] Protein chips based on recombinant antibody fragments:: A highly sensitive approach as detected by mass spectrometry [J].

Borrebaeck, CAK ;

Ekström, S ;

Hager, ACM ;

Nilsson, J ;

Laurell, T ;

Marko-Varga, G .

BIOTECHNIQUES, 2001, 30 (05) :1126-+

[4] Exploring the DNA-binding specificities of zinc fingers with DNA microarrays [J].

Bulyk, ML ;

Huang, XH ;

Choo, Y ;

Church, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) :7158-7163

[5] Quantifying DNA-protein interactions by double-stranded DNA arrays [J].

Bulyk, ML ;

Gentalen, E ;

Lockhart, DJ ;

Church, GM .

NATURE BIOTECHNOLOGY, 1999, 17 (06) :573-577

[6] Double-stranded DNA arrays: next steps in the surface campaign [J].

Carlson, R ;

Brent, R .

NATURE BIOTECHNOLOGY, 1999, 17 (06) :536-537

[7] Massive parallel analysis of DNA-Hoechst 33258 binding specificity with a generic oligodeoxyribonucleotide microchip [J].

Drobyshev, AL ;

Zasedatelev, AS ;

Yershov, GM ;

Mirzabekov, AD .

NUCLEIC ACIDS RESEARCH, 1999, 27 (20) :4100-4105

[8] Fractionation, phosphorylation and ligation on oligonucleotide microchips to enhance sequencing by hybridization [J].

Dubiley, S ;

Kirillov, E ;

Lysov, Y ;

Mirzabekov, A .

NUCLEIC ACIDS RESEARCH, 1997, 25 (12) :2259-2265

[9]

FESENKO DO, 2001, IN PRESS P RUSS ACAD, V381

[10]

Ge H, 2000, Nucleic Acids Res, V28, pe3, DOI 10.1093/nar/28.2.e3

← 1 2 3 4 →