Low-conductance high selective inositol (1,4,5)-triphosphate activated Ca2+ channels in plasma membrane of A431 carcinoma cells

被引：28

作者：

Kiselyov, KI ^{[1
]}

Mamin, AG ^{[1
]}

Semyonova, SB ^{[1
]}

Mozhayeva, GN ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,INST CYTOL,ST PETERSBURG 194064,RUSSIA

来源：

FEBS LETTERS | 1997年 / 407卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

inositol (1,4,5)-trisphosphate; plasma membrane; calcium channel; A431; cell;

D O I：

10.1016/S0014-5793(97)00366-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In many cells, activation of receptors coupled to PIP2 turnover results in Ca2+ release from the intracellular stores accompanied by Ca2+ influx across the PM. It is not well established yet whether Ca2+ influx is activated by IP3 or by an unknown signal generated upon Ca2+ store depletion. We report here a single-channel study of low-conductance IP3-activated channels of very high selectivity for Ca2+ in the PM of A431 carcinoma cells. The channels are strongly potential dependent and sensitive to [Ca2+](i) within the physiological range. The data obtained argues for IP3 acting directly on plasma membrane Ca2+ channels. (C) 1997 Federation of European Biochemical Societies.

引用

页码：309 / 312

页数：4

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