5′-upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration

被引：26

作者：

Cruchaga, Carlos

Vidal-Taboada, Jose M.

Ezquerra, Mario ^{[2
]}

Lorenzo, Elena

Martinez-Lage, Pablo ^{[3
]}

Blazquez, Marta ^{[4
]}

Tolosa, Eduardo ^{[2
]}

Pastor, Pau ^{[1
,5
]}

机构：

[1] Univ Navarra, Ctr Appl Med Res CIMA, Div Neurosci, Neurogenet Lab, Pamplona 31008, Spain

[2] Univ Barcelona, Dept Med, IDIBAPS,CIBERNED,Neurol Serv,Parkinsons Dis & Mov, Hosp Clin Barcelona,Inst Clin Neurociencies, Barcelona, Spain

[3] Fundacio ACE, Barcelona, Spain

[4] Hosp Univ Cent Asturias, Dept Neurol, Oviedo, Spain

[5] Univ Navarra, Clin Univ Navarra, Dept Neurol, Pamplona 31008, Spain

来源：

NEUROBIOLOGY OF DISEASE | 2009年 / 33卷 / 02期

关键词：

Progressive supranuclear palsy; Cortical basal degeneration; Microtubule-associated protein tau; Haplotype; Age at onset; FRONTOTEMPORAL LOBAR DEGENERATION; CORTICOBASAL DEGENERATION; TAU-GENE; ALZHEIMERS-DISEASE; DIAGNOSTIC-CRITERIA; EXTENDED HAPLOTYPE; LOCUS; EXPRESSION; COMMON; INVOLVEMENT;

D O I：

10.1016/j.nbd.2008.09.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two different H1 sub-haplotypes at chromosome 17q21, H1C and H1E'A, have been associated with progressive supranuclear palsy (PSP) and cortical basal degeneration (CBD). We analyzed the SNPs included in the H1C and H1E'A haplotypes in a large Spanish PSP/CBD series and their interaction with age at onset (AAO). Survival analysis of rs1880753 marker was consistently associated with disease risk and with an earlier age at onset under an additive model. Its location at 160 kb and 50 kb upstream of tau and CRHR1 genes, respectively, suggests that it might act as a cis-element that regulates gene expression. Rs45502095(H1) was also associated with AAO under a recessive model. Haplotype analysis failed to replicate the association of H1C and H1E'A haplotypes with PSP/CBD. However, we found a strong association of two H1 sub-haplotypes with PSP and CBD (H1E'C and H1Q), which include MAPT and CRHR1 genes where the risk variant for PSP/CBD could lie. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：164 / 170

页数：7

共 38 条

[1] Association of an extended haplotype in the tau gene with progressive supranuclear palsy [J].