Activin as a morphogen in Xenopus mesoderm induction

被引：92

作者：

McDowell, N

Gurdon, JB

机构：

[1] Wellcome CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England

[2] Univ Cambridge, Dept Zool, Cambridge, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1999年 / 10卷 / 03期

基金：

英国惠康基金;

关键词：

activin; morphogen; mesoderm induction; Xenopus;

D O I：

10.1006/scdb.1999.0307

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Activin, a member of the Transforming Growth Factor beta (TGF-beta) superfamily, can behave as a morphogen in cells of the early Xenopus embryo by inducing a range of mesodermal genes in a concentration-dependent manner. This review examines the behaviour of activin as it forms a morphogen gradient. It also discusses how a cell can perceive its position in a concentration gradient in order to activate appropriate mesodermal gene responses.

引用

收藏

页码：311 / 317

页数：7

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