Asymmetric intramolecular arylcyanation of unactivated Olefins via C-CN bond activation

被引:188
作者
Watson, Mary P. [1 ]
Jacobsen, Eric N. [1 ]
机构
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
关键词
D O I
10.1021/ja805094j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The enantioselective, intramolecular arylcyanation of unactivated olefins via C-CN bond activation has been accomplished using a Ni (0) catalyst and BPh3 co-catalyst. High enantioselectivities are achieved using TangPHOS as a chiral ligand. This method allows the generation of two new C-C bonds and one new quaternary carbon stereogenic center in a single synthetic step, converting readily available benzonitrile substrates into 1,1-disubstituted indanes in 49-85% yield and 92-97% ee.
引用
收藏
页码:12594 / +
页数:3
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