Asymmetric intramolecular arylcyanation of unactivated Olefins via C-CN bond activation

被引：188

作者：

Watson, Mary P. ^{[1
]}

Jacobsen, Eric N. ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 38期

关键词：

D O I：

10.1021/ja805094j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective, intramolecular arylcyanation of unactivated olefins via C-CN bond activation has been accomplished using a Ni (0) catalyst and BPh3 co-catalyst. High enantioselectivities are achieved using TangPHOS as a chiral ligand. This method allows the generation of two new C-C bonds and one new quaternary carbon stereogenic center in a single synthetic step, converting readily available benzonitrile substrates into 1,1-disubstituted indanes in 49-85% yield and 92-97% ee.

引用

页码：12594 / +

页数：3

共 26 条

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