Challenges for biomedical informatics and pharmacogenomics

被引：53

作者：

Altman, RB ^{[1
]}

Klein, TE ^{[1
]}

机构：

[1] Stanford Med Informat, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2002年 / 42卷

关键词：

bioinformatics; pharmacogenetics; computation; databases;

D O I：

10.1146/annurev.pharmtox.42.082401.140850

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacogenomics requires the integration and analysis of genomic, molecular, cellular, and clinical data, and it thus offers a remarkable set of challenges to biomedical informatics. These include infrastructural challenges such as the creation of data models and databases for storing these data, the integration of these data with external databases, the extraction of information from natural language text, and the protection of databases with sensitive information. There are also scientific challenges in creating tools to support gene expression analysis, three-dimensional structural analysis, and comparative genomic analysis. In this review, we summarize the current uses of informatics within pharmacogenomics and show how the technical challenges that remain for biomedical informatics are typical of those that will be confronted in the postgenomic era.

引用

页码：113 / 133

页数：21

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