Chemoenzymatic synthesis of (4S,5R)-5-hydroxy-γ-decalactone

被引：21

作者：

Fadnavis, NW ^{[1
]}

Vadivel, SK ^{[1
]}

Sharfuddin, M ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 1, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 19期

关键词：

D O I：

10.1016/S0957-4166(99)00411-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reduction of ethyl 2-hydroxy-3-oxooctanoate with immobilised baker's yeast at pH 4.0 yields anti-2R,3R-dihydroxy ester with high diastereoselectivity and enantioselectivity (de 70%, ee 80%) which is conveniently converted to (4S,5R)-5-hydroxy-gamma-decalactone. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

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页码：3675 / 3680

页数：6

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