Baker's yeast mediated enantiospecific synthesis of anti-(2R,3R)-p-chloro-3-hydroxytyrosine:: an α-amino-β-hydroxy acid of Vancomycin

被引：18

作者：

Fadnavis, NW ^{[1
]}

Vadivel, SK ^{[1
]}

Sharfuddin, M ^{[1
]}

Bhalerao, UT ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 1, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(97)00603-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Baker's yeast mediated reduction of alpha-azido-beta-keto ester lead to reduction of the carbonyl group with high enantiospecificity and diastereoselectivity at low pH (4.0, e.e. >99%, d.e. 79%). At pH similar to 7, although the enantioselectivity is maintained, the diastereoselectivity is lost. (C) 1997 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：4003 / 4006

页数：4

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