Life before the pre-B cell receptor checkpoint: Specification and commitment of primitive lymphoid progenitors in adult bone marrow

被引：17

作者：

Pelayo, R

Welner, RS

Nagai, Y

Kincade, PW

机构：

[1] Oklahoma Med Res Fdn, Immunobiol & Canc Program, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 01期

关键词：

stem cells; B lymphopoiesis; lymphoid progenitors; transcription factors; stromal cells;

D O I：

10.1016/j.smim.2005.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The production of B cells is a complex process determined by well-timed combinations of intrinsic factors and environmental cues that guide the differentiation of primitive progenitors in the bone marrow. Expression of several key transcription factors and receptor-stromal cell ligand interactions are landmarks of the earliest events in B lymphopoiesis in adult bone marrow. We describe this as a gradual loss of options for other blood cell lineages coincident with gain of essential properties. Experimental, stress or infection-related deregulation may change B cell fate specification, commitment or population dynamics, and consequently the production rate of mature Populations. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：2 / 11

页数：10

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