The Sulfated Polysaccharide Porphyran Reduces Apolipoprotein B100 Secretion and Lipid Synthesis in HepG2 Cells

被引：37

作者：

Inoue, Nao ^{[1
]}

Yamano, Naomi ^{[1
]}

Sakata, Kotaro ^{[1
]}

Nagao, Koji ^{[1
]}

Hama, Yoichiro ^{[1
]}

Yanagita, Teruyoshi ^{[1
]}

机构：

[1] Saga Univ, Dept Appl Biochem & Food Sci, Saga 8408502, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 02期

关键词：

porphyran; apolipoprotein B100; lipid synthesis; HepG2; DRIED NORI; TRIACYLGLYCEROL; METABOLISM; YEZOENSIS; ACID;

D O I：

10.1271/bbb.80688

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein 13100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.

引用

页码：447 / 449

页数：3

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