Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS)
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作者:
Chen, RF
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机构:Chang Gung Mem Hosp, Dept Med Res 12F12L, Kaohsiung 833, Taiwan
Chen, RF
Chang, JC
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机构:Chang Gung Mem Hosp, Dept Med Res 12F12L, Kaohsiung 833, Taiwan
Chang, JC
Yeh, WT
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机构:Chang Gung Mem Hosp, Dept Med Res 12F12L, Kaohsiung 833, Taiwan
Yeh, WT
Lee, CH
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机构:Chang Gung Mem Hosp, Dept Med Res 12F12L, Kaohsiung 833, Taiwan
Lee, CH
Liu, JW
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机构:Chang Gung Mem Hosp, Dept Med Res 12F12L, Kaohsiung 833, Taiwan
Liu, JW
Eng, HL
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机构:Chang Gung Mem Hosp, Dept Med Res 12F12L, Kaohsiung 833, Taiwan
Eng, HL
Yang, KD
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机构:Chang Gung Mem Hosp, Dept Med Res 12F12L, Kaohsiung 833, Taiwan
Yang, KD
机构:
[1] Chang Gung Mem Hosp, Dept Med Res 12F12L, Kaohsiung 833, Taiwan
[2] Chang Gung Mem Hosp, Div Infect Dis, Kaohsiung 833, Taiwan
[3] Chang Gung Mem Hosp, Div Clin Pathol, Kaohsiung 833, Taiwan
The immunopathogenesis of leukopenia and thrombocytopenia in patients with severe acute respiratory syndrome (SARS) is unclear. In order to explore the leukopenia mechanism, we studied 15 SARS patients who were previously healthy, and 15 age-matched normal controls in a paired design. Soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble Fas ligand (sFasL) in plasma were measured by ELISA, and intracellular activated caspase-3 fragment in different leukocytes was determined by flow cytometry. Patients with SARS had significantly lower lymphocyte and platelet counts and significantly higher sVCAM-1 and sFasL levels compared to healthy controls. sVCAM-1 levels correlated negatively with total leukocytes and platelet counts, but positively with plasma sFasL levels. Intracellular cleaved caspase-3 expression was also significantly higher in lymphocytes from SARS patients in acute phase than in convalescent stage. Lymphopenia and thrombocytopenia in SARS patients may be caused, in part, by enhanced vascular sequestration associated with increased sVCAM-1 levels. However, lymphopenia may be due to enhanced cell death. Inhibition of cell adhesion and caspase-3 activation could, therefore, have prevented SARS patients from developing thrombocytopenia and lymphopenia. (c) 2005 Elsevier SAS. All rights reserved.
机构:
New York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Pomeranian Sch Med, Dept Pathol, Szczecin, PolandNew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Grabarek, Jerzy
Du, Litong
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New York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Du, Litong
Johnson, Gary L.
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Immunochem Technol, Bloomington, MN 55431 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Johnson, Gary L.
Lee, Brian W.
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机构:
Immunochem Technol, Bloomington, MN 55431 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Lee, Brian W.
Phelps, David J.
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机构:
Intergen Co, Purchase, NY 10577 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Phelps, David J.
Darzynkiewicz, Zbigniew
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机构:
New York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
机构:
New York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Pomeranian Sch Med, Dept Pathol, Szczecin, PolandNew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Grabarek, Jerzy
Du, Litong
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h-index: 0
机构:
New York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Du, Litong
Johnson, Gary L.
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机构:
Immunochem Technol, Bloomington, MN 55431 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Johnson, Gary L.
Lee, Brian W.
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h-index: 0
机构:
Immunochem Technol, Bloomington, MN 55431 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Lee, Brian W.
Phelps, David J.
论文数: 0引用数: 0
h-index: 0
机构:
Intergen Co, Purchase, NY 10577 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA
Phelps, David J.
Darzynkiewicz, Zbigniew
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USANew York Med Coll, Brander Canc Res Inst, Valhalla, NY 10595 USA