Natural Products and Derivatives as Leads to Cell Cycle Pathway Targets in Cancer Chemotherapy

被引：121

作者：

Newman, David J. ^{[1
]}

Cragg, Gordon M. ^{[1
]}

Holbeck, Susan ^{[2
]}

Sausville, Edward A. ^{[3
]}

机构：

[1] NCI, Nat Prod Branch, Bethesda, MD 20892 USA

[2] NCI, Informat Technol Branch, Bethesda, MD 20892 USA

[3] NCI, Off Associate Director, Dev Therapeut Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA

来源：

CURRENT CANCER DRUG TARGETS | 2002年 / 2卷 / 04期

关键词：

D O I：

10.2174/1568009023333791

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The influence of natural products upon drug discovery in general has been quite impressive; one only has to look at the number of clinically active drugs that are in use in cancer therapy to see how many either are natural products or have a natural product pharmacophore. What is now becoming quite apparent is that materials from natural sources are excellent probes (indicators) for cellular targets that when modulated, may well have a deleterious effect upon the cycling of a tumor cell through the conventional cell cycle. If the particular target is not expressed in normal cell cycling, then a directed "perturbation" of the tumor cell's cycle may well lead to a novel method of treatment for specific tumor types. In this review we have not attempted to be exhaustive but have given a current overview of how natural products from marine, microbial and plant sources have permitted in-depth analyses of various parts of the cell cycle under varying conditions with the ultimate aims of attempting to "control or perturb" the cycling of tumor cells in a fashion that permits their ultimate removal via cellular death, with a minimum of trauma to the host.

引用

页码：279 / 308

页数：30

共 196 条

[21] Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxy) ethylamino-12,13-dihydro-13-(β-D-gluco pyranosyl)5H-indolo[2,3-a]-pyrrolo[3,4-c]-carbazole-5,7(6H)-dione] against pediatric and adult central nervous system tumor xenografts [J].