The amyloid-β precursor protein:: integrating structure with biological function

被引：218

作者：

Reinhard, C ^{[1
]}

Hébert, SS ^{[1
]}

De Strooper, B ^{[1
]}

机构：

[1] KU Leuven & VIB, Ctr Human Genet, Dept Human Genet, Lab Neuronal Cell Biol & Gene Transfer, B-3000 Louvain, Belgium

来源：

EMBO JOURNAL | 2005年 / 24卷 / 23期

关键词：

Alzheimer's disease; amyloid-beta precursor protein; APP; structural and functional relationships;

D O I：

10.1038/sj.emboj.7600860

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteolytic processing of the amyloid-beta precursor protein (APP) generates the A beta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.

引用

收藏

页码：3996 / 4006

页数：11

相关论文

共 118 条

[1] Calcium signals induced by amylold β peptide and their consequences in neurons and astrocytes in culture [J].

Abramov, AY ;

Canevari, L ;

Duchen, MR .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1742 (1-3) :81-87

[2] Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of β-amyloid [J].

Ando, K ;

Iijima, K ;

Elliott, JI ;

Kirino, Y ;

Suzuki, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (43) :40353-40361

[3] Presenilins: molecular switches between proteolysis and signal transduction [J].

Annaert, W ;

De Strooper, B .

TRENDS IN NEUROSCIENCES, 1999, 22 (10) :439-443

[4] A cell biological perspective on Alzheimer's disease [J].

Annaert, W ;

De Strooper, B .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2002, 18 :25-51

[5]

[Anonymous], BIOINORGANIC CHEM CO

[6] Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/mint [J].

Ashley, J ;

Packard, M ;

Ataman, B ;

Budnik, V .

JOURNAL OF NEUROSCIENCE, 2005, 25 (25) :5943-5955

[7] Reactive Oxygen and Nitrogen Species in Alzheimer's Disease [J].

Aslan, Mutay ;

Ozben, Tomris .

CURRENT ALZHEIMER RESEARCH, 2004, 1 (02) :111-119

[8] Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and β-amyloid precursor protein [J].

Baek, SH ;

Ohgi, KA ;

Rose, DW ;

Koo, EH ;

Glass, CK ;

Rosenfeld, MG .

CELL, 2002, 110 (01) :55-67

[9] Structure of the Alzheimer's disease amyloid precursor protein copper binding domain - A regulator of neuronal copper homeostasis [J].

Barnham, KJ ;

McKinstry, WJ ;

Multhaup, G ;

Galatis, D ;

Morton, CJ ;

Curtain, CC ;

Williamson, NA ;

White, AR ;

Hinds, MG ;

Norton, RS ;

Beyreuther, K ;

Masters, CL ;

Parker, MW ;

Cappai, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :17401-17407

[10] Reduced β-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice [J].

Beglopoulos, V ;

Sun, XY ;

Saura, CA ;

Lemere, CA ;

Kim, RD ;

Shen, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (45) :46907-46914

← 1 2 3 4 5 6 7 8 9 10 →