Study of Macrophages in BCG Granulomas in Different Compartments of the Mononuclear Phagocyte System

被引：5

作者：

Arkhipov, S. A. ^{[1
]}

Shkurupy, V. A. ^{[1
]}

Solomatina, M. V. ^{[1
]}

Akhramenko, E. S. ^{[1
]}

Iljine, D. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Res Ctr Clin & Expt Med, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 154卷 / 04期

关键词：

macrophages of BCG-induced granulomas; interleukin-1; alpha; granulocyte-macrophage colony-stimulating factor; tumor necrosis factor-alpha; clusters of differentiation; SPINAL-CORD-INJURY; ACTIVATION; POLARIZATION; INFLAMMATION; MONOCYTES; CELLS;

D O I：

10.1007/s10517-013-1979-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

We studied in vitro morphological and functional properties of macrophages associated with their M1 and M2 polarization in different mononuclear phagocyte compartments during BCG-induced granuloma formation, namely expression patterns of cytokines IL-1 alpha, GM-CSF, TNF-alpha, and clusters of differentiation CD36 and CD16/32. We showed the mosaic pattern of macrophage polarization in BCG granulomatosis manifested by simultaneous formation of different macrophage subpopulations with De1 and De2 phenotypes in the population of mononuclear phagocytes of BCG granulomas and various compartments of the mononuclear phagocyte system. These data clarify the role of the functional polarization of macrophages in the pathogenesis of tuberculosis infection.

引用

页码：467 / 470

页数：4

共 15 条

[1]

Arkhipov S. A., 2012, BYULL EKSPER BIOL, V153, P322

[2]

Macrophage polarization in bacterial infections [J].

Benoit, Marie ;

Desnues, Benoit ;

Mege, Jean-Louis .

JOURNAL OF IMMUNOLOGY, 2008, 181 (06) :3733-3739

[3]

The phagocytes: neutrophils and monocytes [J].

Dale, David C. ;

Boxer, Laurence ;

Liles, W. Conrad .

BLOOD, 2008, 112 (04) :935-945

[4]

Repertoire of microglial and macrophage responses after spinal cord injury [J].

David, Samuel ;

Kroner, Antje .

NATURE REVIEWS NEUROSCIENCE, 2011, 12 (07) :388-399

[5]

Unravelling mononuclear phagocyte heterogeneity [J].

Geissmann, Frederic ;

Gordon, Siamon ;

Hume, David A. ;

Mowat, Allan M. ;

Randolph, Gwendalyn J. .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (06) :453-U92

[6]

Alternative activation of macrophages [J].

Gordon, S .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (01) :23-35

[7]

Alternatively activated macrophages and impaired phagocytosis of S-aureus in chronic rhinosinusitis [J].

Krysko, Olga ;

Holtappels, G. ;

Zhang, N. ;

Kubica, M. ;

Deswarte, K. ;

Derycke, L. ;

Claeys, S. ;

Hammad, H. ;

Brusselle, G. G. ;

Vandenabeele, P. ;

Krysko, D. V. ;

Bachert, C. .

ALLERGY, 2011, 66 (03) :396-403

[8]

The chemokine system in diverse forms of macrophage activation and polarization [J].

Mantovani, A ;

Sica, A ;

Sozzani, S ;

Allavena, P ;

Vecchi, A ;

Locati, M .

TRENDS IN IMMUNOLOGY, 2004, 25 (12) :677-686

[9]

Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression [J].

Martinez, Fernando O. ;

Gordon, Siamon ;

Locati, Massimo ;

Mantovani, Alberto .

JOURNAL OF IMMUNOLOGY, 2006, 177 (10) :7303-7311

[10]

The many faces of macrophage activation [J].

Mosser, DM .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 73 (02) :209-212

← 1 2 →