The state of the art in thin-layer chromatography-mass spectrometry: a critical appraisal

被引：86

作者：

Wilson, ID ^{[1
]}

机构：

[1] Zeneca Pharmaceut, Dept Safety Med, Macclesfield SK10 4TG, Cheshire, England

来源：

JOURNAL OF CHROMATOGRAPHY A | 1999年 / 856卷 / 1-2期

关键词：

mass spectrometry; interfaces; TLC-MS; Detection; TLC; reviews;

D O I：

10.1016/S0021-9673(99)00618-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Thin-layer chromatography-mass spectrometry (TLC-MS) is a readily implemented technique that, in its simplest form, puts few demands on either chromatography or spectrometry. Nevertheless, compared to the situation with high performance liquid chromatography, it is much less highly developed. Currently, the bulk of the practical applications of TLC-MS are directed towards the use of fast atom, or ion bombardment. Recent developments, however, include the use of matrix assisted laser desorption ionisation (MALDI), surface assisted laser desorption (SALDI) and the development of a TLC-electrospray interface. Here, the state of the art of TLC-MS is described and future trends identified. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：429 / 442

页数：14

共 26 条

[1]

Anderson RM, 1998, JPC-J PLANAR CHROMAT, V11, P336

[2] MASS-SPECTROMETRIC DETECTORS FOR SAMPLES SEPARATED BY PLANAR ELECTROPHORESIS [J].

BUSCH, KL .

JOURNAL OF CHROMATOGRAPHY A, 1995, 692 (1-2) :275-290

[3]

BUSCH KL, 1996, HDB THIN LAYER CHROM, P241

[4] DIRECT ANALYSIS OF THIN-LAYER CHROMATOGRAPHY SPOTS BY FAST ATOM BOMBARDMENT MASS-SPECTROMETRY [J].

CHANG, TT ;

LAY, JO ;

FRANCEL, RJ .

ANALYTICAL CHEMISTRY, 1984, 56 (01) :109-111

[5] Thin-layer chromatography mass spectrometry using activated carbon, surface-assisted laser desorption/ionization [J].

Chen, YC ;

Shiea, J ;

Sunner, J .

JOURNAL OF CHROMATOGRAPHY A, 1998, 826 (01) :77-86

[6] The application of high performance liquid chromatography, coupled to nuclear magnetic resonance spectroscopy and mass spectrometry (HPLC-NMR-MS), to the characterisation of ibuprofen metabolites from human urine [J].

Clayton, E ;

Taylor, S ;

Wright, B ;

Wilson, ID .

CHROMATOGRAPHIA, 1998, 47 (5-6) :264-270

[7] THIN-LAYER CHROMATOGRAPHY COMBINED WITH MATRIX-ASSISTED LASER-DESORPTION IONIZATION MASS-SPECTROMETRY [J].

GUSEV, AI ;

PROCTOR, A ;

RABINOVICH, YI ;

HERCULES, DM .

ANALYTICAL CHEMISTRY, 1995, 67 (11) :1805-1814

[8] IMAGING OF THIN-LAYER CHROMATOGRAMS USING MATRIX/ASSISTED LASER DESORPTION/IONIZATION MASS-SPECTROMETRY [J].

GUSEV, AI ;

VASSEUR, OJ ;

PROCTOR, A ;

SHARKEY, AG ;

HERCULES, DM .

ANALYTICAL CHEMISTRY, 1995, 67 (24) :4565-4570

[9]

Klebovich I, 1998, JPC-J PLANAR CHROMAT, V11, P394

[10] THIN-LAYER CHROMATOGRAPHY LASER-DESORPTION OF PEPTIDES FOLLOWED BY MULTIPHOTON IONIZATION TIME-OF-FLIGHT MASS-SPECTROMETRY [J].

KRUTCHINSKY, AN ;

DOLGIN, AI ;

UTSAL, OG ;

KHODORKOVSKI, AM .

JOURNAL OF MASS SPECTROMETRY, 1995, 30 (02) :375-379

← 1 2 3 →