Effects of luteolin 5-O-beta-rutinoside in streptozotocin-induced diabetic rats

被引:31
作者
Zarzuelo, A
Jimenez, I
Gamez, MJ
Utrilla, P
Fernadez, I
Torres, MI
Osuna, I
机构
[1] UNIV GRANADA,FAC MED,DEPT BIOQUIM,E-18071 GRANADA,SPAIN
[2] UNIV GRANADA,FAC CIENCIAS,DEPT BIOL CELULAR,E-18071 GRANADA,SPAIN
关键词
luteolin; 5-O-beta-rutinoside; streptozotocin-induced diabetic rats; pancreatic regeneration;
D O I
10.1016/0024-3205(96)00231-7
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabetic rats, a marked antidiabetic activity was achieved. This effect was evidenced by a significant decrease in glycemia levels (> 50%), a 2.5-fold increase in insulin blood levels and an increase in body and pancreas weight, compared to the diabetic control group.
引用
收藏
页码:2311 / 2316
页数:6
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