Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): Comparison of the performance in classification of ecstasy tablets (Part 2)

被引：19

作者：

Bonadio, Federica ^{[1
]}

Margot, Pierre ^{[1
]}

Delemont, Olivier ^{[1
]}

Esseiva, Pierre ^{[1
]}

机构：

[1] Univ Lausanne, Inst Police Sci, Ecole Sci Criminelles, CH-1015 Lausanne, Switzerland

来源：

FORENSIC SCIENCE INTERNATIONAL | 2008年 / 182卷 / 1-3期

基金：

瑞士国家科学基金会;

关键词：

Ecstasy profiling; Method comparison; SPME; Statistics;

D O I：

10.1016/j.forsciint.2008.10.005

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Headspace solid-phase microextraction (HS-SPME) is assessed as an alternative to liquid-liquid extraction (LLE) currently used for 3,4-methylenedioxymethampethamine (MDMA) profiling. Both methods were compared evaluating their performance in discriminating and classifying samples. For this purpose 62 different seizures were analysed using both extraction techniques followed by gas chromatography-mass spectroscopy (GC-MS). A previously validated method provided data for HS-SPME, whereas LLE data were collected applying a harmonised methodology developed and used in the European project CHAMP. After suitable pre-treatment, similarities between sample pairs were studied using the Pearson correlation. Both methods enable to distinguish between samples coming from the same pre-tabletting batches and samples coming from different pre-tabletting batches. This finding emphasizes the use of HS-SPME as an effective alternative to LLE, with additional advantages Such as sample preparation and a solvent-free process. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 56

页数：5

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