Real-time in vivo dblood-flow imaging by movingscatterer-sensitive spectral-domain optical Doppler tomography

被引：41

作者：

Ren, HW ^{[1
]}

Sun, T

MacDonald, DJ

Cobb, MJ

Li, XD

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Univ Washington, Div Gastroenterol, Seattle, WA 98195 USA

来源：

OPTICS LETTERS | 2006年 / 31卷 / 07期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1364/OL.31.000927

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a moving-scatterer-sensitive optical Doppler tomography (MSS-ODT) technique for in vivo blood flow imaging in real time by using a spectral-domain optical coherence tomography system. In MSS-ODT the influence of stationary scatterers is suppressed by subtracting adjacent complex axial scans before calculating the Doppler frequency shift. We demonstrate that MSS-ODT is a useful technique for accurate determination of blood vessel size by imaging flow in a small capillary tube with a 75 mu m inner diameter. The flow profile obtained with MSS-ODT yields a substantially more accurate tube diameter than that obtained with the conventional phase-resolved method, which underestimates the diameter by about 23%. We also demonstrate that MSS-ODT provides improved sensitivity over the conventional phase-resolved method for imaging in vivo blood flow in small vessels in a mouse ear. (c) 2006 Optical Society of America.

引用

收藏

页码：927 / 929

页数：3

相关论文

共 14 条

[1] Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography [J].

Chen, ZP ;

Milner, TE ;

Srinivas, S ;

Wang, XJ ;

Malekafzali, A ;

vanGemert, MJC ;

Nelson, JS .

OPTICS LETTERS, 1997, 22 (14) :1119-1121

[2] Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].

Choma, MA ;

Sarunic, MV ;

Yang, CH ;

Izatt, JA .

OPTICS EXPRESS, 2003, 11 (18) :2183-2189

[3] Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography [J].

de Boer, JF ;

Cense, B ;

Park, BH ;

Pierce, MC ;

Tearney, GJ ;

Bouma, BE .

OPTICS LETTERS, 2003, 28 (21) :2067-2069

[4] MEASUREMENT OF INTRAOCULAR DISTANCES BY BACKSCATTERING SPECTRAL INTERFEROMETRY [J].

FERCHER, AF ;

HITZENBERGER, CK ;

KAMP, G ;

ELZAIAT, SY .

OPTICS COMMUNICATIONS, 1995, 117 (1-2) :43-48

[5]

Häusler G, 1998, J BIOMED OPT, V3, P21, DOI 10.1117/1.429899

[6] OPTICAL COHERENCE TOMOGRAPHY [J].

HUANG, D ;

SWANSON, EA ;

LIN, CP ;

SCHUMAN, JS ;

STINSON, WG ;

CHANG, W ;

HEE, MR ;

FLOTTE, T ;

GREGORY, K ;

PULIAFITO, CA ;

FUJIMOTO, JG .

SCIENCE, 1991, 254 (5035) :1178-1181

[7] In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomograghy [J].

Izatt, JA ;

Kulkami, MD ;

Yazdanfar, S ;

Barton, JK ;

Welch, AJ .

OPTICS LETTERS, 1997, 22 (18) :1439-1441

[8] Performance of fourier domain vs. time domain optical coherence tomography [J].

Leitgeb, R ;

Hitzenberger, CK ;

Fercher, AF .

OPTICS EXPRESS, 2003, 11 (08) :889-894

[9] Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography [J].

Leitgeb, RA ;

Schmetterer, L ;

Drexler, W ;

Fercher, AF ;

Zawadzki, RJ ;

Bajraszewski, T .

OPTICS EXPRESS, 2003, 11 (23) :3116-3121

[10] Phase-resolved functional optical coherence tomography:: simultaneous imaging of in situ tissue structure, blood flow velocity, standard deviation, birefringence, and Stokes vectors in human skin [J].

Ren, HW ;

Ding, ZH ;

Zhao, YH ;

Miao, JJ ;

Nelson, JS ;

Chen, ZP .

OPTICS LETTERS, 2002, 27 (19) :1702-1704