Evaluation of molecular models for the affinity maturation of antibodies: Roles of cytosine deamination by AID and DNA repair

被引：26

作者：

Samaranayake, M

Bujnicki, JM

Carpenter, M

Bhagwat, AS ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Int Inst Mol & Cell Biol, Lab Bioinformat & Prot Engn, PL-02109 Warsaw, Poland

[3] Adam Mickiewicz Univ, Bioinformat Lab, Inst Mol Biol & Biotechnol, PL-61614 Poznan, Poland

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 02期

关键词：

D O I：

10.1021/cr040496t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review focuses on the humoral response and the progress made in the field since 1999. First, description of some aspects of the immune response relevant to these alterations and a series of programmed DNA alterations initiated by an enzyme, activation-induced deaminase (AID), that are essential for an effective immune response is presented. Enumerated and discussed are: the discovery, biology, structure, and enzymatic activity of AID; role of DNA repair in somatic hypermutation (SHM); mutagenesis by AID; role of transcription in SHM; models for how AID may target transcribing genes; antibody maturation and cancer; and antibody maturation and molecular evolution.

引用

收藏

页码：700 / 719

页数：20

相关论文

共 150 条

[91] Constitutive expression of AID leads to tumorigenesis [J].

Okazaki, I ;

Hiai, H ;

Kakazu, N ;

Yamada, S ;

Muramatsu, M ;

Kinoshita, K ;

Honjo, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) :1173-1181

[92] Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes [J].

Papavasiliou, FN ;

Schatz, DG .

NATURE, 2000, 408 (6809) :216-221

[93] Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity [J].

Papavasiliou, FN ;

Schatz, DG .

CELL, 2002, 109 :S35-S44

[94]

PARTOMO SA, 2005, P NATL ACAD SCI USA, V102, P8656

[95] Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene [J].

Pavlov, YI ;

Rogozin, IB ;

Galkin, AP ;

Aksenova, AY ;

Hanaoka, F ;

Rada, C ;

Kunkel, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :9954-9959

[96] Somatic hypermutation of immunoglobulin genes is linked to transcription initiation [J].

Peters, A ;

Storb, U .

IMMUNITY, 1996, 4 (01) :57-65

[97] AID mutates E-coli suggesting a DNA deamination mechanism for antibody diversification [J].

Petersen-Mahrt, SK ;

Harris, RS ;

Neuberger, MS .

NATURE, 2002, 418 (6893) :99-103

[98] In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1) [J].

Petersen-Mahrt, SK ;

Neuberger, MS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (22) :19583-19586

[99] Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation [J].

Pham, P ;

Bransteitter, R ;

Petruska, J ;

Goodman, MF .

NATURE, 2003, 424 (6944) :103-107

[100]

Phung QH, 1999, J IMMUNOL, V162, P3121

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