Evaluation of molecular models for the affinity maturation of antibodies: Roles of cytosine deamination by AID and DNA repair

被引：26

作者：

Samaranayake, M

Bujnicki, JM

Carpenter, M

Bhagwat, AS ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Int Inst Mol & Cell Biol, Lab Bioinformat & Prot Engn, PL-02109 Warsaw, Poland

[3] Adam Mickiewicz Univ, Bioinformat Lab, Inst Mol Biol & Biotechnol, PL-61614 Poznan, Poland

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 02期

关键词：

D O I：

10.1021/cr040496t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review focuses on the humoral response and the progress made in the field since 1999. First, description of some aspects of the immune response relevant to these alterations and a series of programmed DNA alterations initiated by an enzyme, activation-induced deaminase (AID), that are essential for an effective immune response is presented. Enumerated and discussed are: the discovery, biology, structure, and enzymatic activity of AID; role of DNA repair in somatic hypermutation (SHM); mutagenesis by AID; role of transcription in SHM; models for how AID may target transcribing genes; antibody maturation and cancer; and antibody maturation and molecular evolution.

引用

页码：700 / 719

页数：20

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[51] Different mismatch repair deficiencies all have the same effects on somatic hypermutation: Intact primary mechanism accompanied by secondary modifications [J].