Solid-phase preparation of hydantoins through a new cyclization/cleavage step

被引：60

作者：

Lamothe, M ^{[1
]}

Lannuzel, M ^{[1
]}

Perez, M ^{[1
]}

机构：

[1] Ctr Rech Pierre Fabre, Chim Med 4, F-81106 Castres 06, France

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2002年 / 4卷 / 01期

关键词：

D O I：

10.1021/cc0100520

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient process for the solid-phase synthesis of hydantoins has been developed. The amino acid starting material is anchored to the resin from its carboxylic acid end through formation of a very stable amide bond. After introduction of different functional groups, the cleavage/cyclization step can be performed in acidic or basic conditions.

引用

页码：73 / 78

页数：6

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