Stretch-Induced Biodegradation of Polyelectrolyte Multilayer Films for Drug Release

被引：36

作者：

Barthes, Julien ^{[2
,3
]}

Mertz, Damien ^{[2
,3
]}

Bach, Charlotte ^{[2
,3
]}

Metz-Boutigue, Marie-Helene ^{[2
,3
]}

Senger, Bernard ^{[2
,3
]}

Voegel, Jean-Claude ^{[2
,3
]}

Schaaf, Pierre ^{[1
]}

Lavalle, Philippe ^{[2
,3
]}

机构：

[1] Inst Charles Sadron, CNRS, UPR22, F-67034 Strasbourg 2, France

[2] Inst Natl Sante & Rech Med, INSERM, U977, F-67085 Strasbourg, France

[3] Univ Strasbourg, Fac Chirurg Dentaire, F-67000 Strasbourg, France

来源：

LANGMUIR | 2012年 / 28卷 / 38期

关键词：

DELIVERY;

D O I：

10.1021/la302550q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design of stimuli-responsive polymer assemblies for the controlled release of bioactive molecules has raised considerable interest these two last decades. Herein, we report the design of mechanically responsive drug-releasing films made of polyelectrolyte multilayers. A layer-by-layer (LbL) reservoir containing biodegradable polyelectrolytes is capped with a mechanosensitive LbL barrier and responds to stretching by a total enzymatic degradation of the film. This strategy is successfully applied for the release in solution of an anticancer drug initially loaded within the architecture.

引用

页码：13550 / 13554

页数：5

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