Identification of ins(8;21) with AML1/ETO fusion in acute myelogenous leukemia M2 by molecular cytogenetics

被引：10

作者：

Urioste, M ^{[1
]}

Martínez-Ramírez, A

Cigudosa, JC

Mateo, MS

Martínez, P

Contra, T

Benítez, J

机构：

[1] Inst Salud Carlos III, Ctr Nacl Invest Oncol, Dept Genet Humana, Programa Patol Mol, Madrid, Spain

[2] Hosp Nacl Paraplej, Genet Lab, Toledo, Spain

[3] Hosp Nino Jesus, Dept Oncol, Madrid, Spain

来源：

CANCER GENETICS AND CYTOGENETICS | 2002年 / 133卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(01)00555-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A high percentage of cases of acute myelogenous leukemia (AML) of the M2 subtype show a rearrangement between the AML1 and ETO genes. The detection of the AMLI/ETO fusion has clinical relevance because patients with this subtype have a good prognosis. We present the results of conventional and molecular cytogenetic studies in a patient with acute myelogenous leukemia French-American-British M2 classification, who had a complex karyotype involving chromosomes 8 and 21. Dual-color fluorescence in situ hybridization (FISH) using the AMLI/ETO probe demonstrated a recombination of both genes on an add(8) chromosome. The use of other FISH probes (CEP8, c-myc and TEL21) and spectral karyotyping indicated that AML1/ETO fusion occurred as a consequence of a previously undescribed ins(8;21)(q22; q22.1q22.3). (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：83 / 86

页数：4

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