Signal Recognition Particle: An Essential Protein-Targeting Machine

被引：323

作者：

Akopian, David ^{[1
]}

Shen, Kuang ^{[1
]}

Zhang, Xin ^{[1
]}

Shan, Shu-ou ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82 | 2013年 / 82卷

关键词：

GTPases; protein biogenesis; ribosome; signal recognition particle RNA; signal sequence; BACTERIAL CYTOPLASMIC MEMBRANE; CHLOROPLAST SRP PATHWAY; ENDOPLASMIC-RETICULUM MEMBRANE; ESCHERICHIA-COLI RIBOSOME; F1F0 ATP SYNTHASE; CRYO-EM STRUCTURE; X-RAY-STRUCTURE; CRYSTAL-STRUCTURE; TRIGGER FACTOR; TRANSLATING RIBOSOME;

D O I：

10.1146/annurev-biochem-072711-164732

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The signal recognition particle (SRP) and its receptor compose a universally conserved and essential cellular machinery that couples the synthesis of nascent proteins to their proper membrane localization. The past decade has witnessed an explosion in in-depth mechanistic investigations of this targeting machine at increasingly higher resolutions. In this review, we summarize recent work that elucidates how the SRP and SRP receptor interact with the cargo protein and the target membrane, respectively, and how these interactions are coupled to a novel GTPase cycle in the SRP.SRP receptor complex to provide the driving force and enhance the fidelity of this fundamental cellular pathway. We also discuss emerging frontiers in which important questions remain to be addressed.

引用

页码：693 / 721

页数：29

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