Targeting MYC Translation in Colorectal Cancer

被引：34

作者：

Castell, Alina ^{[1
]}

Larsson, Lars-Gunnar ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, SE-17177 Stockholm, Sweden

来源：

CANCER DISCOVERY | 2015年 / 5卷 / 07期

关键词：

D O I：

10.1158/2159-8290.CD-15-0660

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

There is a great interest in finding ways to inhibit the expression or activity of the "undruggable" MYC, a master regulator of transcription and one of the most deadly oncoproteins in human cancer. In this issue of Cancer Discovery, Wiegering and colleagues find a way of inhibiting translation of MYC in colorectal cancer cells by directly targeting the translation initiation factor eIF4A, resulting in inhibition of MYC-dependent proliferation of colorectal tumor cells in vitro and in vivo. (C) 2015 AACR

引用

页码：701 / 703

页数：3

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