Targeting the translation machinery in cancer

被引：619

作者：

Bhat, Mamatha ^{[1
,2
]}

Robichaud, Nathaniel ^{[1
,3
]}

Hulea, Laura ^{[4
,5
]}

Sonenberg, Nahum ^{[1
,3
]}

Pelletier, Jerry ^{[1
,3
]}

Topisirovic, Ivan ^{[4
,5
]}

机构：

[1] Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada

[2] McGill Univ, Ctr Hlth, Div Gastroenterol, Montreal, PQ H3A 1A1, Canada

[3] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[4] Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

[5] McGill Univ, Dept Oncol, Montreal, PQ H2W 1S6, Canada

来源：

NATURE REVIEWS DRUG DISCOVERY | 2015年 / 14卷 / 04期

关键词：

INITIATION-FACTOR; 4E; MESSENGER-RNA-CAP; ACTIVATED PROTEIN-KINASE; GUANINE-NUCLEOTIDE EXCHANGE; P70; S6; KINASE; SQUAMOUS-CELL CARCINOMA; EUKARYOTIC TRANSLATION; BREAST-CANCER; DEPENDENT TRANSLATION; MAMMALIAN TARGET;

D O I：

10.1038/nrd4505

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and tumour suppressors affect the translation machinery, making aberrant translation a widespread characteristic of tumour cells, independent of the genetic make-up of the cancer. Therefore, therapeutic agents that target components of the protein synthesis apparatus hold promise as novel anticancer drugs that can overcome intra-tumour heterogeneity. In this Review, we discuss the role of translation in cancer, with a particular focus on the eIF4F (eukaryotic translation initiation factor 4F) complex, and provide an overview of recent efforts aiming to 'translate' these results to the clinic.

引用

页码：261 / 278

页数：18

共 292 条

[1] Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway [J].

Adesso, L. ;

Calabretta, S. ;

Barbagallo, F. ;

Capurso, G. ;

Pilozzi, E. ;

Geremia, R. ;

Delle Fave, G. ;

Sette, C. .

ONCOGENE, 2013, 32 (23) :2848-2857

[2]

Alain T, 2012, ONCOTARGET, V3, P1491

[3] eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies [J].

Alain, Tommy ;

Morita, Masahiro ;

Fonseca, Bruno D. ;

Yanagiya, Akiko ;

Siddiqui, Nadeem ;

Bhat, Mamatha ;

Zammit, Domenick ;

Marcus, Victoria ;

Metrakos, Peter ;

Voyer, Lucie-Anne ;

Gandin, Valentina ;

Liu, Yi ;

Topisirovic, Ivan ;

Sonenberg, Nahum .

CANCER RESEARCH, 2012, 72 (24) :6468-6476

[4] Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth [J].

Algire, Carolyn ;

Zakikhani, Mahvash ;

Blouin, Marie-Jose ;

Shuai, Jian Hua ;

Pollak, Michael .

[5] A novel inhibitor of cap-dependent translation initiation in yeast: P20 competes with eIF4G for binding to eIF4E [J].

Altmann, M ;

Schmitz, N ;

Berset, C ;

Trachsel, H .

EMBO JOURNAL, 1997, 16 (05) :1114-1121

[6] LARP1 specifically recognizes the 3′ terminus of poly(A) mRNA [J].

Aoki, Kazuma ;

Adachi, Shungo ;

Homoto, Masae ;

Kusano, Hideo ;

Koike, Katsuyuki ;

Natsume, Tohru .

FEBS LETTERS, 2013, 587 (14) :2173-2178

[7] 4E-Binding protein 1:: A key molecular "Funnel factor" in human cancer with clinical implications [J].

Armengol, Gemma ;

Rojo, Federico ;

Castellvi, Josep ;

Iglesias, Carmela ;

Cuatrecasas, Miriam ;

Pons, Berta ;

Baselga, Jose ;

Ramon y Cajal, Santiago .

CANCER RESEARCH, 2007, 67 (16) :7551-7555

[8] Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin [J].

Assouline, Sarit ;

Culjkovic, Biljana ;

Cocolakis, Eftihia ;

Rousseau, Caroline ;

Beslu, Nathalie ;

Amri, Abdellatif ;

Caplan, Stephen ;

Leber, Brian ;

Roy, Denis-Claude ;

Miller, Wilson H., Jr. ;

Borden, Katherine L. B. .

BLOOD, 2009, 114 (02) :257-260

[9] MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition [J].

Astanehe, A. ;

Finkbeiner, M. R. ;

Krzywinski, M. ;

Fotovati, A. ;

Dhillon, J. ;

Berquin, I. M. ;

Mills, G. B. ;

Marra, M. A. ;

Dunn, S. E. .

ONCOGENE, 2012, 31 (41) :4434-4446

[10] Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells [J].

Avdulov, S ;

Li, S ;

Michalek, V ;

Burrichter, D ;

Peterson, M ;

Perlman, DM ;

Manivel, JC ;

Sonenberg, N ;

Yee, D ;

Bitterman, PB ;

Polunovsky, VA .

CANCER CELL, 2004, 5 (06) :553-563

← 1 2 3 4 5 6 7 8 9 10 →