Targeting the translation machinery in cancer

被引：619

作者：

Bhat, Mamatha ^{[1
,2
]}

Robichaud, Nathaniel ^{[1
,3
]}

Hulea, Laura ^{[4
,5
]}

Sonenberg, Nahum ^{[1
,3
]}

Pelletier, Jerry ^{[1
,3
]}

Topisirovic, Ivan ^{[4
,5
]}

机构：

[1] Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada

[2] McGill Univ, Ctr Hlth, Div Gastroenterol, Montreal, PQ H3A 1A1, Canada

[3] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[4] Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

[5] McGill Univ, Dept Oncol, Montreal, PQ H2W 1S6, Canada

来源：

NATURE REVIEWS DRUG DISCOVERY | 2015年 / 14卷 / 04期

关键词：

INITIATION-FACTOR; 4E; MESSENGER-RNA-CAP; ACTIVATED PROTEIN-KINASE; GUANINE-NUCLEOTIDE EXCHANGE; P70; S6; KINASE; SQUAMOUS-CELL CARCINOMA; EUKARYOTIC TRANSLATION; BREAST-CANCER; DEPENDENT TRANSLATION; MAMMALIAN TARGET;

D O I：

10.1038/nrd4505

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and tumour suppressors affect the translation machinery, making aberrant translation a widespread characteristic of tumour cells, independent of the genetic make-up of the cancer. Therefore, therapeutic agents that target components of the protein synthesis apparatus hold promise as novel anticancer drugs that can overcome intra-tumour heterogeneity. In this Review, we discuss the role of translation in cancer, with a particular focus on the eIF4F (eukaryotic translation initiation factor 4F) complex, and provide an overview of recent efforts aiming to 'translate' these results to the clinic.

引用

页码：261 / 278

页数：18

共 292 条

[11] The selectivity of protein kinase inhibitors: a further update [J].

Bain, Jenny ;

Plater, Lorna ;

Elliott, Matt ;

Shpiro, Natalia ;

Hastie, C. James ;

Mclauchlan, Hilary ;

Klevernic, Iva ;

Arthur, J. Simon C. ;

Alessi, Dario R. ;

Cohen, Philip .

BIOCHEMICAL JOURNAL, 2007, 408 :297-315

[12] MOLECULAR-STRUCTURE OF A MAJOR INSULIN MITOGEN-ACTIVATED 70-KDA S6 PROTEIN-KINASE [J].

BANERJEE, P ;

AHMAD, MF ;

GROVE, JR ;

KOZLOSKY, C ;

PRICE, DJ ;

AVRUCH, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) :8550-8554

[13] Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast Cancer [J].

Baselga, Jose ;

Campone, Mario ;

Piccart, Martine ;

Burris, Howard A., III ;

Rugo, Hope S. ;

Sahmoud, Tarek ;

Noguchi, Shinzaburo ;

Gnant, Michael ;

Pritchard, Kathleen I. ;

Lebrun, Fabienne ;

Beck, J. Thaddeus ;

Ito, Yoshinori ;

Yardley, Denise ;

Deleu, Ines ;

Perez, Alejandra ;

Bachelot, Thomas ;

Vittori, Luc ;

Xu, Zhiying ;

Mukhopadhyay, Pabak ;

Lebwohl, David ;

Hortobagyi, Gabriel N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (06) :520-529

[14] Rapamycin passes the torch: a new generation of mTOR inhibitors [J].

Benjamin, Don ;

Colombi, Marco ;

Moroni, Christoph ;

Hall, Michael N. .

NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (11) :868-880

[15] Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation [J].

Beretta, L ;

Gingras, AC ;

Svitkin, YV ;

Hall, MN ;

Sonenberg, N .

EMBO JOURNAL, 1996, 15 (03) :658-664

[16] ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth [J].

Bi, MX ;

Naczki, C ;

Koritzinsky, M ;

Fels, D ;

Blais, J ;

Hu, NP ;

Harding, H ;

Novoa, I ;

Varia, M ;

Raleigh, J ;

Scheuner, D ;

Kaufman, RJ ;

Bell, J ;

Ron, D ;

Wouters, BG ;

Koumenis, C .

EMBO JOURNAL, 2005, 24 (19) :3470-3481

[17] Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis [J].

Bissler, John J. ;

McCormack, Francis X. ;

Young, Lisa R. ;

Elwing, Jean M. ;

Chuck, Gail ;

Leonard, Jennifer M. ;

Schmithorst, Vincent J. ;

Laor, Tal ;

Brody, Alan S. ;

Bean, Judy ;

Salisbury, Shelia ;

Franz, David N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (02) :140-151

[18] Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model [J].

Bordeleau, Marie-Eve ;

Robert, Francis ;

Gerard, Baudouin ;

Lindqvist, Lisa ;

Chen, Samuel M. H. ;

Wendel, Hans-Guido ;

Brem, Brigitte ;

Greger, Harald ;

Lowe, Scott W. ;

Porco, John A., Jr. ;

Pelletier, Jerry .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (07) :2651-2660

[19] Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A [J].

Bordeleau, ME ;

Mori, A ;

Oberer, M ;

Lindqvist, L ;

Chard, LS ;

Higa, T ;

Belsham, GJ ;

Wagner, G ;

Tanaka, J ;

Pelletier, J .

NATURE CHEMICAL BIOLOGY, 2006, 2 (04) :213-220

[20] Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation [J].

Bordeleau, ME ;

Matthews, J ;

Wojnar, JM ;

Lindqvist, L ;

Novac, O ;

Jankowsky, E ;

Sonenberg, N ;

Northcote, P ;

Teesdale-Spittlet, P ;

Pelletier, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10460-10465

← 1 2 3 4 5 6 7 8 9 10 →