Targeting the translation machinery in cancer

被引：619

作者：

Bhat, Mamatha ^{[1
,2
]}

Robichaud, Nathaniel ^{[1
,3
]}

Hulea, Laura ^{[4
,5
]}

Sonenberg, Nahum ^{[1
,3
]}

Pelletier, Jerry ^{[1
,3
]}

Topisirovic, Ivan ^{[4
,5
]}

机构：

[1] Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada

[2] McGill Univ, Ctr Hlth, Div Gastroenterol, Montreal, PQ H3A 1A1, Canada

[3] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[4] Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

[5] McGill Univ, Dept Oncol, Montreal, PQ H2W 1S6, Canada

来源：

NATURE REVIEWS DRUG DISCOVERY | 2015年 / 14卷 / 04期

关键词：

INITIATION-FACTOR; 4E; MESSENGER-RNA-CAP; ACTIVATED PROTEIN-KINASE; GUANINE-NUCLEOTIDE EXCHANGE; P70; S6; KINASE; SQUAMOUS-CELL CARCINOMA; EUKARYOTIC TRANSLATION; BREAST-CANCER; DEPENDENT TRANSLATION; MAMMALIAN TARGET;

D O I：

10.1038/nrd4505

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and tumour suppressors affect the translation machinery, making aberrant translation a widespread characteristic of tumour cells, independent of the genetic make-up of the cancer. Therefore, therapeutic agents that target components of the protein synthesis apparatus hold promise as novel anticancer drugs that can overcome intra-tumour heterogeneity. In this Review, we discuss the role of translation in cancer, with a particular focus on the eIF4F (eukaryotic translation initiation factor 4F) complex, and provide an overview of recent efforts aiming to 'translate' these results to the clinic.

引用

页码：261 / 278

页数：18

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