The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

被引：207

作者：

Koscielny, Gautier ^{[1
]}

Yaikhom, Gagarine ^{[2
,3
]}

Iyer, Vivek ^{[4
]}

Meehan, Terrence F. ^{[1
]}

Morgan, Hugh ^{[2
,3
]}

Atienza-Herrero, Julian ^{[2
,3
]}

Blake, Andrew ^{[2
,3
]}

Chen, Chao-Kung ^{[1
]}

Easty, Richard ^{[4
]}

Di Fenza, Armida ^{[2
,3
]}

Fiegel, Tanja ^{[2
,3
]}

Grifiths, Mark ^{[4
]}

Horne, Alan ^{[4
]}

Karp, Natasha A. ^{[4
]}

Kurbatova, Natalja ^{[1
]}

Mason, Jeremy C. ^{[1
]}

Matthews, Peter ^{[4
]}

Oakley, Darren J. ^{[4
]}

Qazi, Asfand ^{[4
]}

Regnart, Jack ^{[4
]}

Retha, Ahmad ^{[2
,3
]}

Santos, Luis A. ^{[2
,3
]}

Sneddon, Duncan J. ^{[2
,3
]}

Warren, Jonathan ^{[1
]}

Westerberg, Henrik ^{[2
,3
]}

Wilson, Robert J. ^{[4
]}

Melvin, David G. ^{[4
]}

Smedley, Damian ^{[4
]}

Brown, Steve D. M. ^{[2
,3
]}

Flicek, Paul ^{[1
]}

Skarnes, William C. ^{[4
]}

Mallon, Ann-Marie ^{[2
,3
]}

Parkinson, Helen ^{[1
]}

机构：

[1] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Cambridge CB10 1SD, England

[2] Med Res Council Harwell, Mammalian Genet Unit, Harwell OX11 0RD, Oxon, England

[3] Med Res Council Harwell, Mary Lyon Ctr, Harwell OX11 0RD, Oxon, England

[4] Wellcome Trust Sanger Inst, Mouse Informat Grp, Cambridge CB10 1SA, England

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

GENOME-WIDE; RESOURCES; TOOL;

D O I：

10.1093/nar/gkt977

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated 'data wranglers' work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease. As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases.

引用

页码：D802 / D809

页数：8

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