A Continuous Flow Solution to Achieving Efficient Aerobic Anti-Markovnikov Wacker Oxidation

被引：50

作者：

Bourne, S. L. ^{[1
]}

Ley, S. V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 10期

关键词：

aerobic Wacker oxidation; gas-liquid flow; microreactors; palladium catalysis; tube-in-tube; CATALYZED OXIDATION; ORGANIC-SYNTHESIS; MOLECULAR-OXYGEN; GASEOUS AMMONIA; CHEMISTRY; HYDROGENATION; ALDEHYDES; ALCOHOLS; STYRENES; OLEFINS;

D O I：

10.1002/adsc.201300278

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An aerobic anti-Markovnikov Wacker oxidation for the flow-synthesis of arylacetaldehydes is reported. In the process, flow chemistry techniques have provided a means to control and minimise the over-oxidation of sensitive products. The reaction showed general applicability to various functionalised styrenes and provided a process capable of a multi-gram scale.

引用

页码：1905 / 1910

页数：6

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